Synthesis of Phosphate Monoesters chymistry

The following paper presents an efficient and environmentally friendly method for producing phosphate monoesters, in which the only byproduct is water, as opposed to a different reaction, which also gives off pyridine hydrochloride as a byproduct.
The paper describes that it was experimentally determined that the best solvent, tertiary amine, and catalyst (or nucleophilic base) for the reaction are DMF-nitroethane, tributylamine, and N-butylimidazole, respectively, each giving the highest yield. This is a summary of the main reaction discussed in the paper.
* The article states that water was constantly removed by azeotropic reflux, so that the reverse reaction was prevented.



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