Synthesis of S-Adenosylmethionine Synthetase chymistry

The sulfonium salt S-adenosylmethionine is one of the most widely used biological methylating agents. It is formed by the ATP activation of methionine. One of the most benifical uses of this salt is to convert norepinephrine to epinephrine (adrenaline). Many times this conversion happens in flight or fight organs, which leads to vasodilatation. This vasodilatation in turn leads to an increased blood flow to the organ/tissue or interest.

The reaction shown is the formation of S-Adenosylmethionine. This process occurs in two steps as can be seen. The first step cleaves the whole phosphate of the ATP. However before the sulfur of methionine attacks the C5` atom of ATP (via SN2) there is further hydrolysis of the cleaved tri-phosphate into two inorganic phosphates (di and mono).

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